Volume 8 | Issue 12

 Abstract

Jaivik Krishi Our Jaivik Khadon Ka Mrida Ke Bhautik, Rasayanik Avm Jaivik Gunon Par Prabhav Tatha Jaivik Khad Prabandhan

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Jaivik Krishi Our Jaivik Khadon Ka Mrida Ke Bhautik, Rasayanik Avm Jaivik Gunon Par Prabhav Tatha Jaivik Khad Prabandhan

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Abstract Molecular hybridization of nucleic acids is the process in which two single-stranded nucleic acid molecules with complementary base sequences form a double-stranded nucleic acid molecule. Nucleic acid hybridization technology is a fundamental tool in molecular biology, and has been applied in various fields such as detection of gene expression, screening specific clone from cDNA or genomic library, determining the location of a gene in chromosome and diagnosis of diseases. Cage like property for eg graphene or glue like bio material from spider or even polymer can bind rapid growth of cell for its binding nature at micro level or can trap bacterial or viral growth by trapping within Net like structure. The idea of Quantum Dots may be implied to identify such net as drug to separate from diseases infected Zone. Sometime electrification or by application of Radioactivity through this net may reduce harmful diseases spreading. Molecular hybridization a useful tool in the design, trapping of new generation drug prototypes using the sequencing of Nucleic acids for a particular patient. Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this paper, we described several examples of different strategies for drug design, discovery and pharmaco modulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infectious, anticancer, cardio- and neuroactive properties. By this molecular hybridization concept in the field of genetic engineering and as well as molecular biology, formation of a partially or wholly complementary nucleic acid duplex as association of single strands, usually between DNA and RNA strands (previously associated or un associated DNA , RNA strands.). These are used to detect an isolated specific genetically initiated sequences as measured sequencing homology, or define other characteristics of one or both strands. If we can detect the particular cause of critical disease like Parkinson, Cancer or AIDS for a particular patient. We can synthesis the new drug design for that patient to treat them for complete cure in this molecular hybridisation concept. So this is a new generation concept for developing drug as well as the cause of the particular diseases for a particular patient. Not only that by fusing more than one drugs structure components by Molecular hybridisation concept we can make a single drug for a patient with multiple affected diseases using computer simulation more modern method in the field of medicinal chemistry. The idea will show us to find the way of sustainable health and immortality in future.

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Keywords: Molecular hybridization, Drug design, Hybrid compounds, Pharmacophoric group combination, DNA and RNA Sequencing.

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Sanskrit literature is not only rich in the grammatical composition and romantic expression but also in knowledge about environment, its destruction and the need for its protection which come up in many contexts every now and then whenever any attempt is made to study this literature. Starting from the Vedic age till now it carries a number of appearances in the writings of scholars. This need to be explored in detail as the vast size and span of it leaves enough scope for researchers to dig up those sources of knowledge. In this paper different sources of knowledge are studied to find out the concern and knowledge on environment and its protection. It includes all those valuable sources to do maximum justice to the objective of the paper.

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environmental concern, Sanskrit, text, Vedas, puranas

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Dalits have been facing discrimination and oppression at the hands of the upper-caste since centuries in both rural and urban spaces. However, in rural spaces it is even more rampant and aggressive as compared to in the urban spaces. With the development and expansion of modern cities in India in the early 1900s, the cities provided space for many Dalit families to put behind their identities as merely Dalits and acquire the respect that every human deserves. This paper attempts to read Narendra Jadhav�s Untouchables: My Family�s Triumphant Journey Out of the Caste System in Modern India, a biographical account of his father�s life to understand and explore caste discrimination and its transformation across generations in both rural and urban settings.

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biography, caste, Dalit, discrimination, emancipation, rural, urban

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Current Liquidity position of UGVCL Company

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Liquidity analysis of UGVCL COMPANY

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This paper is concerned with the construction of the composite development index for all districts taking agricultural, industrial and infrastructural indicators to assess the relative position and direction of change during the period of study. In the first part, indicators found significant for construction of Composite Index for overall development are discussed. Composite Indices for overall development for 1995-96 and 2007-08 were constructed and compared in the second part. Last part of this paper discusses the pattern of change in the era of economic reforms in terms of impact on different levels of development between districts and the pace of development in relatively under-developed districts. An attempt has been made to trace out correlates of development

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Era of Economic Reforms,Composite Index,Correlates of Development

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Agmatine is the product of arginine decarboxylation and can be hydrolyzed by agmatinase to putrescine, the precursor for biosynthesis of higher polyamines, spermidine, and spermine. Besides being an intermediate in polyamine metabolism, recent findings indicate that agmatine may play important regulatory roles in mammals. Agmatine, 4-aminobutyl guanidine, has recently been found in various mammalian organs and is thought to act as a neurotransmitter or neuromodulatory agent. The present study is to do a review on agmatine and its synthesized analogues till now for agmatinase inhibitory action. Agmatinase is a binuclear manganese metalloenzyme and belongs to the ureohydrolase superfamily that includes arginase, formiminoglutamase, and proclavaminate amidinohydrolase. Compared with a wealth of structural information available for arginases, no three dimensional structure of agmatinase has been reported. Agmatinase is an enzyme which blocks the mammalian agmatine which is ultimately responsible for the agmatine degradation in the body. Agmatinase is an enzyme which regulates the half life of agmatine in the brain. Hence a selective inhibitor of brain agmatinase is required. Several derivatives of agmatine are synthesized previously for agmatinase inhibitory activity but none of them showed selective inhibition. PZC (Piperazinecarboxamidine) is a derivative of agmatine or guanidine is expected to show selective inhibition of human agmatinase. A detailed review is carried out in order to understand the agmatinase inhibitor.

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Agmatinase, Neurotransmitter, Neuromudulator, Guanidine, Piperazinecarboxamidine, Putrescine, arginase, Catecholamines, Nitric oxide synthase (NOS), N-methyl, D-aspartate (NMDA)

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The current scenario of environmental degradation is enforcing every individual to focus on sustainability. Green baking aims is to take a proactive action towards environmental protection. Banking industry have a vital impact on society as this can impact our day to day life. This study will focus on the impact of adopting green banking on all the stakeholders like customer, employee and organization itself. After facing many environmental disasters every individual wants to contribute to changing scenarios. Every organization runs its business for profit-making, and hence it is necessary for an organization to know its profit before adopting any changes for sustainability. This study is a literature review of green banking and its benefit for every stakeholder of banks. Researcher has considered more than 50 studies for this study. The objectives of this paper are to study practices of green banking and its impact on customer satisfaction. After find impact on customer researcher again find impact on employee of bank. In last researcher find overall impact on organization.

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Environment, Sustainability, Green Banking, Customer, Employee, Organization.

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With the exponentially rising affluent middle-class income category urban Indians, the lifestyle of the people has seen a significant change since the last decade. The role of brands tends to play a much influencing role in today�s generation especially for this category of people to suit themselves with the urban social life. The people belonging to Generation Z are witnessed to be a large chunk of consumers in India who behave extremely different from generation X and Y thereby calling in for a pressing need to analyse their behaviour across genders. The present study aims to evaluate the difference in footwear purchasing behaviour of generation Z Indians across males and females and also check the role of sales promotion when it comes to purchasing of branded footwear from branded outlets. The data is collected from 385 respondents from different parts of the country and the difference in behaviour is further analyzed with the help of Levene�s test of homogeneity, independent t-test and Cohen�s d. The study interprets certain distinct findings like women being more involved in short term buying behaviour as in comparison to men, the stronger influence of sales promotion over tools upon women than men and such others.

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Generation Z, Sales Promotion, Footwear, Retail, India.

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A.K. Ramanujan�s colleagues in the university of Chicago, Susanne and Lloyd Rudolph, writes about the most distinguishing characteristics of his personality is his �humanity� and �modesty�. As a man and a writer, he avoided loud and big gestures. He was preoccupied with the small, the insignificant and the everyday experiences. Ramanujan has descended from an orthodox Brahmin lineage and had firsthand knowledge about the hypocrisies that had polluted such an ancient and indigenous religion as the Sanatan Dharma or Hinduism. So as a poet, linguist, folklorist, translator and literary theorist, Ramanujan�s lifelong endeavor was to make a more humane society and his poetry is a rich treasure-trove of his humanistic concerns.

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A. K. Ramanujan, Humanism, Indian Society, Modernism.

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Data Vending is one of the most useful and highly effective concepts that have been utilized to implement data sharing for various different approaches and applications. The Data is one of the most essential commodity that can be highly useful in achieving various machine learning and artificial intelligence applications. But there are certain problems with this approach, due to the fact that the data might contain personally identifiable information or sensitive information. This leads to a lack of trust between the Data vendor and aggregator which can lead to the termination of data sharing. Therefore, there is need for a system that can provide effective security to tampering and increase trust between the data vendor and aggregator. To achieve a system capable of improving the trust in the data sharing paradigm a collection of researches have been analyzed in this research article. This research article has been highly useful in developing our approach which implements the use of the Distributed Blockchain Platform to eliminate the security concerns. The proposed approach will be effectively outlined in the upcoming editions of this research.

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Blockchain, Distributed Systems, Natural Language Processing.

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Indian Government, at all levels, announces Welfare Schemes for a cross section of the society from time to time. These schemes could be either Central, State specific or a joint collaboration between the Centre and the States. In this section, we have attempted to provide you an easy and single point access to information about several welfare schemes of the Government and their various aspects including eligible beneficiaries, types of benefits, scheme details etc. The �e-Governance service at Panchayat level for help people� is a system which provides the welfare scheme at Panchayat level accessible to the citizens. Using this system any citizen can know what and all the Govt. Schemes available for Children, Women, Disabled People, Labor, etc. Based on this information, a citizen can register and apply for the scheme to get benefit from the Govt. The Govt. representative Officer will verify the necessary documents for the applied scheme and approves the request. A citizen can view all available schemes as well he/she can know the status of their request through this portal.

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MMP, E-Government, ICT, GDP, Security, Cloud, Technical Challenging, Interoperability, Requirement Analysis.

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The aspect of medicines supplied to patients. clinch that the medicines prescribed to patients are suitable. For the purpose of Safety and Efficacy of medicines it should be benefit for a patient and drug ability to produce the optimum results. Secretion of insulin which result hyperglycemia comes under the group of Diabetes mellitus, insulin action, or both and obesity is a chronic metabolic disorder caused by an imbalance between energy intake and expenditure. The present work is about anti-diabetic as well as anti-obesity drug, which is formulated using extract of fenugreek, green coffee beans, cumin seed and trachyspermum ammi (ajwain) by using in-vitro ?-amylase inhibitory activities of plant extracts. The purpose of this study is to evaluate the ?-amylase inhibitory activity of different plant extracts of against porcine pancreatic amylase in vitro. Overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. The regulation of fatty acid and triglyceride availability in biological responses depends on the activity of lipolytic enzymes present in fatty acid metabolism in adipose tissue. This project is about antidiabetic as well as antiobesity drug, which is made with the using Fenugreek (methi) is widely used for antidiabetic as well as obesity control, Green Coffee Beans (coffee Arabica) which is used in weight loss, lowers the blood pressure, Cumin Seed (Bunium bulbocastanum) which is used as diabetes, gastrointestinal disturbances and also helpful in weight loss andTrachyspermum ammi (Ajwain) it also work for diabetes.This is helpful for the people those who are suffering from diabetes and as well as obesity.

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Plant extract, Antidiabetic and anti-obesity activity, Trachyspermum ammi, in-vitro ?-amylase inhibitory activities, Cumin Seed.

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A transdermal patch may be a medicated adhesive patch that is placed on the skin to deliver a particular dose of medication through the skin and into the blood. Often, this promotes healing to an injured area of the body. A plus of a transdermal drug delivery route over alternative forms of medication delivery like oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, sometimes through either a porous membrane covering a reservoir of medication or through body heat melting skinny layers of medication embedded within the adhesive. Transdermal drug delivery offers controlled release of the drug into the patient, it permits a gradual blood level profile, leading to reduced general aspect effects and, sometimes, improved efficacy over alternative dosage forms. The main objective of transdermal drug delivery system is to deliver medication into circulation through skin at predetermined rate with minimal inter and intrapatient variations.

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Topical, Reservoir, Transdermal, Epidermis

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ABSTRACT: COVID-19 is a popular term to the present day world. It has got attention of the entire world due to its deadly character. Our day to day life has been totally disrupted due to the outbreak of COVID-19. We have become bound to stay at home. Industries, transportation, hotel, restaurant, offices, schools, colleges, universities �all are closed due to the announcement of lockdown. Even at the phase of unlock educational institutions are closed. Regular classes are being hampered. Quite a good proportion of teachers became restless by being away from teaching-learning process. They were in search of ways and means to reach their students. As a way out there came the process of online education. The present paper seeks to analyse whether online education is just a stop gap arrangement or it is a paradigm shift in mode of teaching. Online education may be just a stop gap arrangement, it can never be an alternative mode of teaching learning to face to face class room teaching learning which had, has and will have a justified essence in the literature of education.

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Key Words: COVID-19, Online Education, Self motivation, Self control, Blended mode of teaching

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Avascular necrosis of the hip joint is an increasingly common cause of musculoskeletal impairment and presents a significant diagnostic and therapeutic issue, although patients are initially asymptomatic, avascular necrosis typically progresses to joint destruction of the femoral head, requiring complete replacement of the hip, usually before the fifth decade. There are no signs and symptoms in the early stage, but the bone collapses in the advanced stage and displays several symptoms such as groin or hip pain radiating to the weight bearing aggravated buttocks, thigh or knee. If the condition is not treated as the pain gradually increases and worsens with time and use, pain at rest increases at the later stage, which can be worse during the night and may also be associated with morning stiffness. Due to its preventive, promotional, prophylactic and rejuvenating properties, and offering a radical remedy, Panchakarma is a very special therapeutic technique. In the present case study, Mansarasa Basti and herbo-mineral calcium supplements were given to patients diagnosed with avascular necrosis of hip joint. Evaluation was carried out on subjective criteria and it was concluded that in the case of AVN, the Mansarasa Basti provided substantial gains in improving functional movement.

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Asthikshaya, Avascular Necrosis, Mansarasa Basti

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Background: Breastfeeding is the universally preferred method of feeding a newborn. Breast engorgement is a condition that affects breastfeeding mothers early in the postpartum. The discomfort and tenderness as a result of the engorgement is a major contributing factor to the early cessation of breastfeeding. Many treatments for breast engorgement have been attempted and explored. The studies revealed that lactational counseling can increase the knowledge of mother in reducing the incidence of breast engorgement and in improving the new born feeding behaviour. AIM: the aim of the study was to prevent breast engorgement and newborn feeding behavior. Objectives:1. Determine the effectiveness of lactational counseling on breast engorgement among ante natal mothers., 2.Determine the effectiveness of lactational counseling on newborn feeding behaviour among antenatal mothers.3.Associate the breast engorgement and newborn feeding behaviour with selected back ground variables of the antenatal mother. Methodology: 50 antenatal mothers from CEmONC center, Madanapalli were selected by using convenience sampling method. Results: Study results shows that among 50 primi antenatal mothers� majority 62% (31) had inadequate knowledge, 34% (17) had moderate knowledge and only 4% (2) had adequate knowledge in pre-test. Whereas in post-test 8% (16) had inadequate knowledge and 50% (25) had adequate knowledge and 34% (17) had moderate knowledge on newborn feeding behavior. Study findings revealed that among 50 primi antenatal mother�s majority 64% (32) had inadequate knowledge, 30% (15) had moderate knowledge and only 6% (3) had adequate knowledge in pre-test. Whereas in post-test 7% (14) had inadequate knowledge, 54% (27) had adequate knowledge and 32% (16) had moderate knowledge on breast engorgement.

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modified breast engorgement, newborn feeding behavior, antenatal mothers.

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The Judiciary in India has earned the reputation as an environmentalist due to the various decisions which have been credited with changing the whole environmental protection discourse in India. The Courts have not only been helpful in limiting the environmental degradation but they have also been instrumental in preventing the reversible damage to the ecology. However, the approach of the Court has been diminishing over the last few years and it has reached to a point where the initial gains made by the Courts activism are being eroded gradually. Apart from this there is the persistent issue of the fixation of the Court with taking up the matters which garner the maximum number of headlines in the news. There is some proof for the criticism of the Court for its manifest class bias while disposing off the environmental matters where the underprivileged sections of the society are left to fend for themselves while the concerns of the affluent sections of the society are passed off as the vision of the Court for conservation. In this paper the author has tried to analyse the growth and development along with the discontents in the environmental jurisprudence of the Court. Certain course correction measures are also suggested by the author which will help in restoring the strong role being played by the Court in environment protection.

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Environmental conservation, Judicial Activism, Right to Life, Mega Projects,Livelihood

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Progress of human civilization, advancement in medical science and healthier lifestyle of people has obviously increased life of Old Age. Ironically, changed socio-economic conditions have completely changed living conditions of older persons in the country. In changed set up, old people face increased incidences of age discrimination, ageism, elder abuse and mistreatment of older community, which are strictly against any civilized society. Elderly abuse is not new in any society or country whether developed, under developed or developing country. Initially what we called a family issue has now been reported as a social welfare issue as abuse of elderly related to their problem of aging has become a major concern area of criminal justice

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Abuse, Justice, Elder.

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Women are considered as dependent objects for men in this patriarchal society. They dominate her to show their power to the world to maintain their self created status. The word hero is not simply an appellation given to a man, who possesses the only action and kung-fu flicks, rather a hero is someone who expects nothing in return, reckon with their problems as well as endeavors for others too. Hero word is not related to any gender and sex, it can be anyone, a woman, a man even a child can also be a hero. This word concerns with ability, sacrifices, virtuosity, determination, and courage. This paper can be divided into three parts. The first part deals with the circumstances of Celie in which she is forced to live. The second part discusses how she raises her voice after being a voiceless woman for a long period. Finally, in the last part, it presents an example of a Shero who has changed her deplorable circumstances into a prosperous life.

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Suppression, Patriarchy, Sexism, Casteism, Domination, Voice, Self identity.

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