Published Paper Details:

A novel series of halogen-substituted heterocyclic derivatives based on the 1,2,4-triazole scaffold was synthesized and evaluated for their biological potential. In the present investigation, chloro-, bromo-, and fluoro-substituted derivatives of 5-(4,7-dihydrothiazolo[5,4-c]pyridin-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol were successfully prepared through an efficient synthetic protocol. The structures of the synthesized compounds were confirmed using various spectroscopic techniques, including FT-IR, 1H NMR, 13C NMR, and mass spectrometry. The spectral data were found to be in good agreement with the proposed molecular structures. The newly synthesized derivatives were further screened for their biological activities against selected microbial strains to evaluate their antimicrobial potential. The results revealed that several halogen-substituted compounds exhibited significant inhibitory activity compared to the standard drugs. The presence of electron-withdrawing halogen substituents such as chloro, bromo, and fluoro on the aromatic ring was found to influence the biological activity of the synthesized molecules. These findings suggest that the incorporation of halogen atoms into the triazole-thiazolopyridine framework may enhance biological efficacy and could provide promising lead structures for the development of new bioactive heterocyclic compounds.