Published Paper Details:

Depression is a major global health concern requiring safer and more effective therapeutic interventions. The present study focuses on the green synthesis of iron nanoparticles (FeNPs) using Curcuma longa (turmeric) extract and the evaluation of their antidepressant activity. The plant extract, rich in bioactive compounds such as curcumin, was utilized as a reducing and stabilizing agent for nanoparticle synthesis. The synthesized FeNPs were characterized using standard analytical techniques including UV-Visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD) to confirm their formation, size, morphology, and functional groups. The antidepressant activity was evaluated using established in vivo models such as the Forced Swim Test (FST) and Tail Suspension Test (TST). Behavioral parameters including immobility time were recorded and compared with standard antidepressant drugs. The results demonstrated that the green synthesized FeNPs exhibited significant antidepressant-like activity, potentially due to their antioxidant and neuroprotective properties. The synergistic effect of iron nanoparticles and Curcuma longa phytoconstituents may contribute to modulation of oxidative stress and neuroinflammation pathways. This study highlights the potential of plant-mediated iron nanoparticles as a novel, eco-friendly, and effective approach for the management of depression, requiring further investigation for clinical applications.