Published Paper Details:

Due to bacterial infections, especially from Aeromonas hydrophila, a main pathogen in freshwater aquaculture, global aquaculture suffers significant difficulties. Diseases, including motile aeromonad septicaemia (MAS), which this bacterium produces, have substantial death rates and financial losses. Using antibiotics extensively to fight A. hydrophila has resulted in the development of antibiotic-resistant strains, therefore reducing the efficacy of therapy and generating public health issues. Consequently, there is an increasing demand for substitute, environmentally acceptable, sustainable methods to control bacterial diseases. Promising is bacteriophage therapy, in which particular bacteria are targeted and killed using viruses (bacteriophages). Phages have great selectivity, infecting just the intended bacteria, and they could fight strains resistant to many drugs. Phages can also self-replicate at the infection site, therefore reducing ecological disturbance and causing a weak immunological reaction in fish. The promise of phage therapy as a focused substitute for antibiotics in aquaculture in the control of A. hydrophila is investigated in this review. It goes over the benefits of phage therapy over conventional antibiotics, summarises present studies, and outlines future research requirements. The application in aquaculture is the public view of bacteriophage treatment, including elements of safety, efficacy, and cultural acceptance.