Published Paper Details:

A systematic and comparative study of oxidation of a few ? -amino acids like Glycine DL- Leucine ,DL-Isoleucine, DL-alanine, DL-Phenyl Alanine by using 2,6-dichloroquinone-4-chloro-imide has been carried out in aqueous acetic acid-sodium acetate mixtures. The kinetic orders aresimilar that is first order in oxidizing agent for all the substrates. The substrate dependence is first order for all the substrates. If we increase sodium acetate concentration leads to increases the reaction rate. In these analysis we observed that in these oxidations is with alanine as standard, substrates with electron releasing groups like Glycine and alanine and substrates with electron with drawing groups like Phenyl alanine , serine ,Aspartic acid exhibited higher kinetic rates. This shows that there is a dual mechanism operating in these oxidations. log k1 vs ? plot is not linear as two lines intersect giving two different slopes. The slopes are -2.45 for substrates with electron releasing groups and +1.67 for substrates with electron with drawing groups. Hepler's treatment has been applied to understand the nature of entropy-enthalpy relationship on the kinetics of these reactions. Finally a synchronous oxidative decarboxylation process has been postulated to explain the oxidation of these ? -amino acids. The major products are the nitriles.