Published Paper Details:

Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by hormonal imbalance, chronic inflammation, and metabolic irregularities. Conventional treatments often present limitations, including side effects and poor patient compliance. In this study, a novel herbal transdermal patch technology was developed as a non-invasive approach to support hormonal regulation and symptom management in PCOS. The formulations incorporated standardized herbal extracts of Ashwagandha (Withania somnifera), Fenugreek (Trigonella foenum-graecum), Cinnamon (Cinnamomum verum), and Spearmint (Mentha spicata) plants known for their phytochemicals with adaptogenic, insulin-modulating, anti-androgenic, and anti-inflammatory actions. Their chemical constituents, including withanolides, trigonelline, cinnamaldehyde, and rosmarinic acid, play a crucial role in restoring hormonal balance, particularly by regulating cortisol levels, improving insulin sensitivity, and reducing excess androgens associated with PCOS.Two types of transdermal patches were formulated: a pre-period patch, designed to mitigate premenstrual discomfort and early hormonal fluctuations, and a continuous-period patch, intended for sustained support throughout the menstrual cycle. The patches were prepared using suitable polymers and evaluated for drug-polymer compatibility, physicochemical properties, and stability. Compatibility studies confirmed the absence of major interactions between the herbal extracts and excipients, ensuring effective transdermal permeation. Preliminary observations indicated favorable mechanical strength, uniform drug distribution, and potential for controlled release.Overall, the developed herbal transdermal patches demonstrate promise as an innovative and effective delivery system for PCOS management by providing targeted hormone- balancing support through natural phytochemicals. Further in vitro and in vivo studies are recommended to validate therapeutic efficacy and long-term safety.