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Background: Gratitude is an important construct in positive psychology and has been associated with happiness, emotional well-being, life satisfaction, and positive interpersonal relationships. College students aged 18-25 years experience various academic, emotional, social, and career-related challenges that may influence their quality of life. Examining the relationship between gratitude and quality of life may contribute to a better understanding of psychological well-being among young adults. Objective: This study aimed to assess gratitude and quality of life among college students aged 18-25 years and to examine the relationship between these variables. Methods: A quantitative cross-sectional correlational study was conducted among 60 college students aged 18-25 years selected through convenience sampling. Gratitude was assessed using the Gratitude Questionnaire-6 (GQ-6), while quality of life was measured using the Quality of Life Scale-Revised (QLS-R). Descriptive statistics, Pearson's product-moment correlation, independent-samples t-test, and regression analysis were used for data analysis. Results: Participants had a mean quality of life score of 45.52 (SD = 9.82) and a mean gratitude score of 4.40 (SD = 0.86). Pearson's correlation analysis revealed a negligible negative and statistically non-significant relationship between gratitude and quality of life (r = -0.017, p > .05). No statistically significant gender differences were observed in quality of life (t = 0.47, p = .64) or gratitude (t = 0.62, p = .53). Regression analysis also indicated that gratitude did not significantly predict quality of life. Conclusion: Gratitude was not significantly associated with quality of life among the college students included in this study. Although gratitude is widely recognized as a positive psychological strength, the present findings suggest that quality of life among college students may be influenced by multiple psychological, social, academic, and contextual factors. Further research involving larger and more diverse samples is recommended to clarify the relationship between gratitude and quality of life among young adults.