Published Paper Details:

Abstract: Memory dysfunction or memory disorders are now becoming a health problem that negatively impacts quality of life and functional independence. Nisy?n in Unani medicine is a disorder in which memory, reasoning, and imagination become defective. The objective of this review is to give an integrative discussion on the Unani perspective of Nisy?n, its pathophysiology, presentation, lifestyle factors, and treatment approach supported by recent scientific findings. A comprehensive literature search was undertaken using electronic databases, including PubMed, Google Scholar, Scopus, and ScienceDirect, to identify relevant English-language publications. Classical Unani literature was reviewed using authoritative texts, including Al-Qanun fi'l-Tibb, Sharah Asbab, Tibb-e-Akbar, Zakheera Khwarzam Shahi, Khazain-ul-Advia, and other standard Unani references. As per the classical literature, the Nisy?n arises from derangements of Quwwat-e-Hafiza, Quwwat-e-Mufakkira, and Quwwat-e-Khayal mostly due to Su'-e-Mizaj of the brain. Both classical and modern literature indicate the role of modifiable lifestyle factors which includes poor dietary habits, digestion, sleep problems, inactivity, psychological distress, and metabolic disorders in causing memory dysfunction. Many Muqawwi-e-Hafiza drugs have shown antioxidant, neuroprotective, anti-inflammatory, and cognitive effects in experimental studies. However, evidence is inadequate for some formulations.