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management of Iron Deficiency Anemia (Pandu Roga) Background: Iron Deficiency Anemia (IDA) is a common nutritional deficiency disorder worldwide and a major public health concern in developing countries, including India. It predominantly affects children, women of reproductive age, and pregnant women, leading to reduced physical capacity, impaired quality of life, and increased morbidity. In Ayurveda, the clinical manifestations of IDA closely resemble Pandu Roga, which is associated with Rasa Dhatu Kshaya, Agnimandya, and imbalance of Tridosha. Objective: To systematically review clinical evidence on the efficacy and safety of selected Ayurvedic formulations in the management of Iron Deficiency Anemia (Pandu Roga). Materials and Methods: A systematic review with descriptive synthesis was conducted using six peer-reviewed Indian clinical studies published between 2012 and 2025. Studies evaluating Ayurvedic herbal or herbomineral formulations in human subjects with defined hematological outcomes were included. Data on hemoglobin levels, red blood cell indices, iron parameters, clinical symptoms, and adverse drug reactions were extracted and analyzed. Results: More than 650 patients aged 2-60 years were included, with a predominance of female participants. Formulations such as Dhatri Lauha, Punarnavadi Mandura, Trikatrayadi Lauha, Loha Churna Vatakam, Yogaraja Rasayana, and Pandughni Vati showed significant improvement in hemoglobin levels, red blood cell indices, and iron parameters. Clinical symptoms improved in up to 85% of patients. No serious adverse drug reactions were reported. Conclusion: Ayurvedic formulations appear effective and safe for managing Iron Deficiency Anemia. Their multidimensional action offers a holistic alternative or adjunct to conventional iron therapy, though larger randomized controlled trials are required for confirmation. management of Iron Deficiency Anemia (Pandu Roga) Background: Iron Deficiency Anemia (IDA) is a common nutritional deficiency disorder worldwide and a major public health concern in developing countries, including India. It predominantly affects children, women of reproductive age, and pregnant women, leading to reduced physical capacity, impaired quality of life, and increased morbidity. In Ayurveda, the clinical manifestations of IDA closely resemble Pandu Roga, which is associated with Rasa Dhatu Kshaya, Agnimandya, and imbalance of Tridosha. Objective: To systematically review clinical evidence on the efficacy and safety of selected Ayurvedic formulations in the management of Iron Deficiency Anemia (Pandu Roga). Materials and Methods: A systematic review with descriptive synthesis was conducted using six peer-reviewed Indian clinical studies published between 2012 and 2025. Studies evaluating Ayurvedic herbal or herbomineral formulations in human subjects with defined hematological outcomes were included. Data on hemoglobin levels, red blood cell indices, iron parameters, clinical symptoms, and adverse drug reactions were extracted and analyzed. Results: More than 650 patients aged 2-60 years were included, with a predominance of female participants. Formulations such as Dhatri Lauha, Punarnavadi Mandura, Trikatrayadi Lauha, Loha Churna Vatakam, Yogaraja Rasayana, and Pandughni Vati showed significant improvement in hemoglobin levels, red blood cell indices, and iron parameters. Clinical symptoms improved in up to 85% of patients. No serious adverse drug reactions were reported. Conclusion: Ayurvedic formulations appear effective and safe for managing Iron Deficiency Anemia. Their multidimensional action offers a holistic alternative or adjunct to conventional iron therapy, though larger randomized controlled trials are required for confirmation.