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Ayurveda is a comprehensive system of medicine that encompasses extensive knowledge related to health, disease prevention, environmental factors, and toxicology. Among its eight specialized branches, Agada Tantra is dedicated to the study of poisons (Visha), their effects on the human body, and their management. The Ayurvedic concept of Visha includes a wide spectrum of toxic substances capable of producing local as well as systemic manifestations. The skin (Twak), being the largest and most exposed organ of the body, is particularly susceptible to toxic insults resulting from direct contact, ingestion, inhalation, or chronic exposure to poisonous substances. Classical Ayurvedic texts describe various categories of poisons, including Sthavara Visha (plant and mineral poisons), Jangama Visha (animal poisons), Garavisha (artificial or compound poisons), Dushivisha (cumulative or latent toxins), and Upavisha (semi-poisonous substances). Exposure to Sthavara Visha often manifests as inflammatory skin reactions comparable to contact dermatitis, while Jangama Visha may present with urticarial and allergic skin manifestations. Furthermore, the concepts of Dushivisha and Garavisha closely resemble modern toxicological conditions arising from prolonged exposure to pesticides, industrial chemicals, environmental pollutants, cosmetic products, occupational hazards, and other cumulative toxins. Dermatological manifestations such as erythema, itching, swelling, discoloration, rashes, vesicles, ulceration, and various forms of Twak Vikara serve as important indicators in the diagnosis, prognosis, and assessment of toxic exposure. Ayurvedic literature provides detailed descriptions of these manifestations along with their pathogenesis and therapeutic management. Among the various antidotal formulations described in Agada Tantra, Panchashirisha Agada is regarded as one of the most effective remedies for Vishajanya Vyadhi due to its potent Vishaghna (anti-toxic), Kushthaghna (anti-dermatotic), Kandughna (anti-pruritic), Twachya (skin-beneficial), Varnya (complexion-enhancing), and Shothaghna (anti-inflammatory) properties. It can be administered both internally and externally depending on the clinical presentation. This review aims to explore the dermatological manifestations associated with various forms of Visha described in Ayurveda and correlate them with contemporary dermatological and toxicological concepts. Integrating classical Ayurvedic knowledge with modern scientific understanding may contribute to improved identification, prevention, and management of toxin-induced skin disorders and highlight the clinical relevance of Agada Tantra in present-day healthcare.