Published Paper Details:

Acne vulgaris is a common chronic inflammatory disorder of the pilosebaceous units, primarily caused by excess sebum production, microbial colonisation (Cutibacterium acnes), follicular blockage, and inflammation. Conventional therapies such as antibiotics and retinoids are associated with adverse effects, including irritation, dryness, and microbial resistance. Polyherbal formulations have gained increasing attention due to their synergistic therapeutic effects, safety, and reduced toxicity. The present study focuses on the formulation and evaluation of a polyherbal anti-acne gel, incorporating natural ingredients with proven anti-acne properties. Neem (Azadirachta indica) and Aloe vera (Aloe barbadensis Miller) were selected as key herbal components due to their antimicrobial, anti-inflammatory, and healing properties. Multiple gel formulations were developed by varying the concentration of these herbal extracts, and a comparative evaluation was carried out. The prepared formulations were evaluated for physicochemical parameters such as pH, viscosity, spreadability, extrudability, drug content, and antimicrobial activity. Stability studies were also conducted. Among the formulations, F2 exhibited optimal characteristics in terms of consistency, stability, and antimicrobial activity. The study concludes that polyherbal anti-acne gel is a safe and effective alternative to conventional treatments, and the combination of neem and aloe vera provides enhanced therapeutic benefits.