Published Paper Details:

Acne vulgaris is a multifactorial inflammatory skin disorder that commonly affects adolescents and young adults. The limitations and side effects of conventional therapies such as antibiotics and retinoids have encouraged the search for safer, plant-based alternatives. The present study focuses on the development and evolution of a herbal transdermal acne patch incorporating Neolamarckia cadamba leaf extract, known for its antimicrobial, antioxidant, and anti-inflammatory properties. The work aimed to formulate, optimize, and evaluate a hydrocolloid-based herbal patch capable of providing controlled release and localized treatment of acne lesions. Fresh leaves of N. cadamba were collected, authenticated, and subjected to hydroalcoholic extraction. Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, and triterpenoids. Various patch prototypes were developed using combinations of polymers such as hydroxypropyl methylcellulose (HPMC), polyvinyl alcohol (PVA), and sodium carboxymethylcellulose (CMC), along with plasticizers including glycerol and propylene glycol. Formulations were optimized based on physical properties, extract compatibility, adhesion, and drug release behavior. The optimized patch demonstrated satisfactory mechanical strength, flexibility, and sustained release of active compounds for up to 24 hours. In vitro antimicrobial studies against Cutibacterium acnes and Staphylococcus epidermidis revealed significant inhibition zones, confirming the antibacterial potential of the extract. Stability testing under accelerated conditions showed no significant changes in appearance or activity, indicating good formulation stability. A preliminary pilot study on human volunteers demonstrated reduced inflammatory lesion count and improved skin appearance with no major adverse effects. The study concludes that Neolamarckia cadamba-based herbal acne patches offer a promising natural, effective, and patient-friendly alternative for acne management. Future work will focus on standardization of active phytoconstituents, large-scale clinical trials, and commercialization strategies for this innovative herbal transdermal delivery system.