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ABSTRACT Background: Chronic bronchitis is a major component of Chronic Obstructive Pulmonary Disease (COPD) and is strongly associated with long-term smoking. Smoking cessation is the most effective intervention to slow disease progression. However, knowledge and attitude toward smoking cessation among patients remain inadequate in many settings. Objectives: 1. To assess the knowledge regarding smoking cessation among chronic bronchitis patients. 2. To assess the attitude toward smoking cessation among chronic bronchitis patients. 3. To determine the association between knowledge and attitude scores with selected demographic variables. Methods: A descriptive cross-sectional study was conducted among 100 chronic bronchitis patients in selected hospitals of Indore, Madhya Pradesh. A structured knowledge questionnaire and Likert attitude scale were used. Data were analyzed using descriptive and inferential statistics. Results: The findings revealed that 58% of patients had moderate knowledge, 28% had inadequate knowledge, and 14% had adequate knowledge. Regarding attitude, 62% showed a favorable attitude, 25% moderately favorable, and 13% unfavorable attitude. A significant association was found between knowledge and education level (p < 0.05). Conclusion: The study concludes that although patients have a moderately favorable attitude toward smoking cessation, knowledge levels remain insufficient. Structured educational interventions are recommended.