Published Paper Details:

Syzygium cumini (L.) Skeels, commonly known as jamun, Indian blackberry, or black plum, is a tropical fruit tree belonging to the Myrtaceae family and is widely found in the Indian subcontinent. It has gained considerable attention for its potential role in managing hyperglycemia associated with diabetes mellitus, a metabolic disorder characterized by inadequate insulin production or impaired glucose regulation.This review focuses on the antihyperglycemic activity of S. cumini, particularly its seeds, which are an important by-product rich in various bioactive compounds. Phytochemical studies have identified the presence of several secondary metabolites such as flavonoids, polyphenols, terpenoids, and alkaloids including jambosine and jamboline, which are believed to contribute to its therapeutic effects.The antidiabetic action of S. cumini is associated with multiple mechanisms, including improvement of glucose homeostasis, stimulation of pancreatic ?-cell function, enhancement of insulin secretion, and inhibition of carbohydrate-digesting enzymes like ?-amylase and ?-glucosidase. Experimental studies in streptozotocin-induced diabetic animal models have demonstrated a dose-dependent reduction in blood glucose levels and HbA1c. Furthermore, computational studies suggest that compounds such as kaempferol and gallic acid exhibit strong interactions with key enzymes involved in carbohydrate metabolism.Clinical findings also indicate that the administration of standardized seed powder can significantly reduce fasting as well as postprandial blood glucose levels. Although S. cumini is generally considered safe, further research is needed to standardize extraction methods and develop advanced drug delivery systems to enhance its bioavailability and therapeutic effectiveness