Published Paper Details:

Background: Autoimmune disorders represent a significant global health burden, often characterized by the body's failure to distinguish "self" from "non-self." While modern immunology focuses on cytokine signaling and genetic predisposition, the role of metabolic integrity remains an emerging area of interest. In Kayachikitsa, the foundational principle "Rogah Sarvepi Mandagnau" suggests that all systemic diseases originate from impaired digestive fire (Jatharagni). This review aims to critically analyze the literary evidence linking Jatharagni to Vyadhikshamatva (immunity) and its role in the pathogenesis of autoimmune conditions.Methods: A comprehensive literary search was conducted across the Brihatrayi (Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya) and their respective commentaries. Keywords included Agni-mandya, Ama, Ojas, Vyadhikshamatva, and Srotodushti. Relevant concepts were synthesized and correlated with modern immunological theories of gut dysbiosis and molecular mimicry.Results: The review identifies a definitive "Jatharagni-Vyadhikshamatva Axis." Chronic Mandagni leads to the formation of Ama (toxic metabolic by-products), which acts as an endogenous antigen. The literature suggests that Ama impairs the Sukshma-bhaga (subtle essence) of Dhatu formation, ultimately depleting Ojas (the biological essence of immunity). In this state of metabolic chaos, the Doshas undergo Prasara (circulation) and lodge in weakened Srotas (channels), triggering an inflammatory response that mirrors modern autoimmune cascades. The study highlights that Vyadhikshamatva is not a static trait but a dynamic byproduct of optimal Ahara-paka (digestion).Conclusion: The Ayurvedic perspective offers a unique approach to autoimmunity by prioritizing metabolic correction over immunosuppression. Restoring the Jatharagni-Vyadhikshamatva Axis through Deepana, Pachana, and Shodhana provides a robust theoretical framework for the integrative management of chronic autoimmune disorders.