Published Paper Details:

Fluorenyl-based hydrazide derivatives represent a promising class of compounds with potential antimicrobial properties due to their lipophilicity and structural versatility. In this study, a series of Hydrazide -- N'-(9H-fluoren-9-ylidene) acetohydrazide, 2-chloro-N'-(9H-fluoren-9-ylidene) acetohydrazide, N'-(9H-fluoren-9-ylidene)-2-methylpropanehydrazide, N'-(9H-fluoren-9-ylidene)-2,2-dimethylpropanehydrazide, N'-(2,7-dichloro-9H-fluoren-9-ylidene) benzohydrazide, and N'-(2,7-dichloro-9H-fluoren-9-ylidene)decanehydrazide were synthesized through condensation of 2,7-dichlorofluorenone hydrazone with various acid chlorides. The compounds were characterized using spectroscopic techniques including IR and NMR. Their antimicrobial activity was assessed against Gram-positive and Gram-negative bacterial strains, as well as Candida albicans. Several derived hydrazides exhibited moderate to significant antimicrobial activity, especially against E. coli and Candida albicans. These results reinforce the potential of fluorenyl-hydrazide as a platform for antimicrobial drug design.