Published Paper Details:

Drug resistance has emerged as a major challenge in the management of chronic, infectious, metabolic, and inflammatory diseases in contemporary medicine. Despite appropriate diagnosis and standard therapeutic regimens, a subset of patients shows poor or diminishing response to pharmacological interventions. Ayurveda, with its individualized approach to diagnosis and treatment, offers a unique framework to understand inter-individual variability in drug response through the concept of Prakriti. Prakriti, the innate psychosomatic constitution of an individual determined at conception, governs physiological functions, metabolic capacity, disease susceptibility, and therapeutic responsiveness. This paper proposes an Ayurvedic hypothesis that drug resistance may be partially explained by Prakriti-specific variations in Agni, Dhatu Paka, Srotas, and Koshta, leading to altered drug assimilation, metabolism, distribution, and action. The article critically examines classical Ayurvedic principles, correlates them with contemporary concepts of pharmacogenomics and personalized medicine, and proposes a Prakriti-based model for understanding drug resistance. This conceptual framework opens new avenues for integrative research, individualized therapeutics, and optimized drug selection in both Ayurveda and modern medicine.