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Background: Electroconvulsive Therapy (ECT) is a well-established therapeutic intervention used in psychiatry for the management of severe mental disorders such as major depression, schizophrenia, and catatonia. Proper handling of the ECT machine and adherence to procedural standards by nursing personnel are essential to ensure patient safety and treatment effectiveness. However, gaps in knowledge and practice among staff nurses may affect the quality of care provided during ECT procedures. Objectives: 1. To assess the existing knowledge and practice regarding ECT machine among staff nurses working in psychiatry wards. 2. To evaluate the effectiveness of a structured teaching programme on knowledge and practice regarding ECT machine. 3. To find the association between post-test knowledge and practice scores with selected demographic variables. Methods: A quantitative pre-experimental one-group pretest-posttest design was adopted. Staff nurses working in psychiatry wards of a selected hospital in Ayodhya, Uttar Pradesh were selected using a convenient sampling technique. Data were collected using a structured knowledge questionnaire and observational checklist for practice. Following pretest assessment, a structured teaching programme related to ECT machine operation, safety precautions, preparation, and nursing responsibilities was administered. Post-test assessment was conducted after the intervention to determine effectiveness. Results: The findings indicated significant improvement in knowledge and practice scores after administration of the structured teaching programme. The calculated t-value showed statistical significance at p < 0.05, suggesting that the intervention was effective in enhancing nurses' competency related to ECT machine handling. Conclusion: The structured teaching programme significantly improved the knowledge and practice of staff nurses regarding ECT machine, highlighting the importance of continuous nursing education in psychiatric care settings.