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Background: Prolonged smart device use among young adults has become increasingly common due to academic, social, and entertainment needs. Excessive screen time contributes to sedentary behaviour, which is a growing risk factor for cardiovascular diseases. College students often lack adequate awareness regarding the health consequences associated with physical inactivity and prolonged smart device exposure. Educational interventions such as handouts may serve as an effective strategy to enhance awareness and promote healthier lifestyle behaviours. Objectives: 1. To assess the baseline awareness regarding sedentary lifestyle and cardiovascular risk factors associated with prolonged smart device use among college students. 2. To evaluate the effectiveness of educational handouts on improving awareness levels. 3. To determine the association between awareness scores and selected demographic variables. Methods: A quantitative pre-experimental one-group pretest-posttest design was adopted. The study was conducted among college students at a selected urban college in Gandhinagar, Gujarat. Participants were selected using a convenient sampling technique. Baseline awareness was assessed using a structured knowledge questionnaire. Educational handouts explaining sedentary lifestyle risks, cardiovascular complications, and preventive strategies were distributed. Post-test assessment was conducted after the intervention to measure improvement in awareness. Data were analyzed using descriptive and inferential statistics. Results: The findings revealed that students had moderate awareness during the pretest. Post-intervention scores showed significant improvement in awareness levels, indicating the effectiveness of educational handouts. A significant association was observed between awareness scores and selected demographic variables such as daily smart device usage and physical activity levels. Conclusion: Educational handouts were found to be an effective, simple, and cost-effective strategy for improving awareness regarding sedentary lifestyle and cardiovascular risk factors among college students. Integrating awareness programs within college health promotion initiatives may help reduce long-term cardiovascular risk.