Published Paper Details:

In traditional and modern techniques herbal drugs have been widely utilised due to their therapeutic potential and safety profile. However, their clinical application is often limited because their poor solubility, low bioavailability, chemical instability, rapid metabolism, and lack of site-specific delivery. And in order to overcome these limitations, nanotechnology enabled novel drug delivery systems (NDDS) has emerged as a promising strategy to enhance the therapeutic performance of herbal formulations. This review article provided a comprehensive overview of NDDS employed for herbal drugs, focusing on their design strategies, their mechanism of action and clinical relevance. Various carrier systems such as liposomes, phytosomes, nanoparticles, nano emulsions, microspheres, hydrogels, transdermal patches, plant-derived nanovesicles etc. are discussed with representative examples of clinically important phytoconstituents which includes curcumin, silymarin, resveratrol, and epigallocatechin gallate. Additionally, recent advances in marketed formulations, translational challenges, regulatory concerns, and safety considerations are critically examined. The review article also highlights future perspectives, emphasizing green nanotechnology, personalized medicine, and AI-assisted formulation designs too. Overall, nanotechnology-based NDDS offer significant potential to bridge the gap between traditional herbal medicine and modern clinical therapeutics.