Published Paper Details:

Background: Kleda is the functional fluid component of the body responsible for maintaining Snigdhata, Mardavata, and Picchilata of tissues and for supporting normal Dhatu Poshana and Srotasa Pravahana. Its pathological state, Vikrita Kleda, leads to abnormal fluid accumulation and plays a central role in the Samprapti of Sotha, a Kleda-pradhana Vyadhi characterized by Utseda due to Tridosha Prakopa and Rasavaha Srotas Dushti. Despite its importance, Kleda has largely remained a conceptual entity with limited objective evaluation. Aim: To establish Sothagata Vikrita Kleda as an etiopathological entity and to study its correlation with laboratory parameters in Sotha. Materials and Methods: This observational study included 100 patients (20 each of Prameha, Sthoulya, Sotha, Kustha, and Vrana). Vikrita Kleda was assessed using classical Lakshanas along with laboratory investigations including inflammatory markers, renal function tests, metabolic parameters, and protein status. Results: Sotha patients showed the highest expression of Vikrita Kleda, with Utseda (100%), Anga Vivarnata (95%), Gaurava (90%), and Anavasthita Sotha and Ushma (85%). Laboratory findings revealed raised ESR (70%), CRP (60%), renal and metabolic derangements, hypoproteinemia (50%), and hypoalbuminemia (40%), indicating impaired Kleda Nishkramana and Dhatu Kshaya. Conclusion: The study provides objective evidence that Sothagata Vikrita Kleda is a measurable and clinically significant pathological state.