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Background: Kleda is a fundamental yet underexplored concept in Ayurvedic pathophysiology, representing the functional expression of Jala Mahabhuta responsible for tissue moisture, lubrication, and metabolic fluid balance. In its vitiated state (Vikrita Kleda), it plays a crucial role in the development of Kapha-dominant disorders, eg. Sthaulya and Prameha. Classical texts describe Sthaulya as a Medo-pradoshaja and Santarpanajanya Vyadhi, wherein deranged Meda Dhatu and impaired Medodhatwagni lead to excessive internal moisture and metabolic imbalance. However, Kleda has rarely been assessed as a measurable etiopathological entity using objective parameters. Aim: To evaluate Sthaulyagata Vikrita Kleda as an etiopathological factor and to explore its correlation with selected laboratory parameters. Methods: A clinical observational study was conducted on 100 subjects, comprising 20 patients each of Prameha, Sthaulya, Sotha, Kushta, and Vrana. Assessment was performed using a specially designed proforma based on classical Ayurvedic features of Kapha Vriddhi and Ama, supported by laboratory investigations including serum cholesterol and body mass index (BMI). A diagnosis of Vikrita Kleda was considered when four or more predefined features were present. Results: Sthaulya patients exhibited the highest prevalence of Vikrita Kleda features, particularly Swedadhikya (100%), Kshuda Adhikya (95%), and Pipasa Adhikya (90%). Prameha subjects showed overlapping Kleda manifestations, indicating a shared metabolic pathology. Elevated serum cholesterol was predominantly observed in Sthaulya and Prameha, while BMI analysis confirmed severe obesity in the majority of Sthaulya patients. Other disease groups demonstrated localized or minimal Kleda involvement. Conclusion: The study validates Sthaulyagata Vikrita Kleda as a central etiopathological factor in Sthaulya and allied metabolic disorders. The observed correlation between classical Kleda features and modern laboratory parameters highlights the potential of integrative assessment in understanding disease pathogenesis and supports the clinical relevance of Kleda as a functional marker of metabolic derangement in Ayurveda