Published Paper Details:

Background: In Ayurveda, Kleda represents the physiological moisture essential for tissue integrity, while its pathological state (Vikrita Kleda) plays a central role in the pathogenesis of several metabolic and systemic disorders. Prameha is classically described as a Kleda-pradhana Vyadhi, yet its etiopathological expression in relation to measurable laboratory parameters remains underexplored. Aim: To establish Pramehagata Vikrita Kleda as a distinct etiopathological entity and to evaluate its association with laboratory parameters in Prameha and related disorders. Methods: A clinical observational study was conducted on 100 subjects, comprising 20 patients each of Prameha, Sthoulya, Sotha, Kustha, and Vrana. Assessment of Vikrita Kleda was carried out using a specially designed proforma derived from classical Ayurvedic descriptions of Kapha vriddhi and Ama, supported by objective laboratory investigations including fasting and postprandial blood glucose, blood urea, serum creatinine, and urine examination. The presence of Vikrita Kleda was confirmed when four or more predefined clinical features were observed. Results: Prameha patients demonstrated the highest incidence of Vikrita Kleda features, particularly Avila Mutrata (100%), Mutramadhurya (75%), Pipasa Adhikya (80%), and Nidra Adhikya (80%). Laboratory findings revealed consistently elevated fasting (100%) and postprandial blood sugar levels (80%), along with a higher incidence of raised blood urea (65%) and serum creatinine (70%), suggesting systemic involvement of Kleda dushti. Urine analysis showed a predominance of cloudy and turbid urine in Prameha, whereas other disease groups largely exhibited normal urinary parameters. Conclusion: The study validates Pramehagata Vikrita Kleda as a key etiopathological factor in Prameha, with clear clinical and laboratory correlations. Biochemical parameters and urine characteristics may serve as objective indicators of Kleda dushti, supporting an integrative approach to understanding Prameha through both Ayurvedic principles and modern diagnostics.