Published Paper Details:

Autoimmune diseases are chronic disorders in which the body's immune system mistakenly targets its own tissues, leading to persistent inflammation and progressive damage. These conditions are rising globally, with post-pandemic data revealing a surge in autoimmune markers, particularly in developing nations like India. Despite advancements in immunology and biotechnology, the complexity of autoimmunity demands an integrative and individualized approach. Ayurveda, the ancient Indian system of medicine, offers a profound understanding of immune regulation through its core concepts of Agni (digestive/metabolic fire), Ama (toxic metabolic residue), Ojas (vital immunity essence), and Vyadhikshamatva (natural disease resistance). This review explores autoimmune diseases through both biomedical and Ayurvedic lenses. Modern etiological factors such as genetic predisposition, environmental triggers, hormonal influences, and immune dysregulation are compared with Ayurvedic Nidana such as Mandagni, Ama, Dosha Prakopa, and Oja-Kshaya. The article highlights how Ayurvedic pathophysiology Dosha-Dushya Sammurchana correlate with immune hyperreactivity and tissue damage. Furthermore, a comprehensive Ayurvedic management protocol is proposed, involving Panchakarma, Rasayana Chikitsa, Achara Rasayana, and herbal immunomodulators like Ashwagandha and Guduchi. Emphasis is laid on rejuvenating Ojas, restoring Agni, and removing Ama to arrest the autoimmune cascade. Integrating classical Ayurvedic wisdom with modern diagnostics may lead to more sustainable, personalized, and holistic outcomes in managing autoimmune disorders. This article encourages further research and clinical validation of integrative therapies for long-term remission and improved quality of life in patients with autoimmunity.