Published Paper Details:

Duchenne Muscular Dystrophy (DMD) is a rare and severe genetic disorder that primarily affects young boys, leading to progressive muscle weakness and disability. This article provides a comprehensive overview of DMD, including its etiology, clinical manifestations, diagnostic methods, treatment options, ongoing research efforts, and potential future therapies. By exploring the underlying genetic mutation, pathophysiology, and impact on affected individuals and their families, this article aims to shed light on the challenges faced by patients with DMD and the strides made in understanding and managing this debilitating condition. Duchenne Muscular Dystrophy (DMD) is a rare and debilitating genetic disorder that primarily affects young boys, causing progressive muscle weakness and loss of mobility. This paper provides an in-depth examination of the pathophysiology, genetic basis, clinical manifestations, diagnostic methods, and current therapeutic strategies for DMD. The disorder arises from mutations in the dystrophin gene, leading to the absence of this essential protein in muscle cells. As a result, muscle fibers are susceptible to damage and degeneration, ultimately leading to severe muscle wasting. Early diagnosis through genetic testing and clinical evaluation is crucial for timely intervention, as the natural course of the disease is characterized by loss of ambulation and life-threatening complications. Various therapeutic approaches, such as corticosteroids, physical therapy, and emerging gene-based therapies, are discussed in detail. This review aims to provide a comprehensive understanding of DMD and highlight the ongoing research efforts to improve the quality of life for affected individuals.