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Published Paper Details:
Paper Title
Solubility Enhancement of Spironolactone by Fluid Bed Hot Melt Granulation Technique
Authors
Vijay Suresh Surve, Dr. Sonia Singh, Dr. Rahul Aware, Ganesh Kute
Keywords
Spironolactone, Hot Melt Granulation, Solubility, Dissolution, Tablet
Abstract
Spironolactone (SPL) is potassium-sparing diuretics. SPL is Biopharmaceutics Classification System (BCS) Class II drug. its poor aqueous solubility presents a significant challenge as it can lead to Slow dissolution and Reduced bioavailability. in present investigation the solubility of Spironolactone is enhanced by Hot Melt Granulation using wax co-solvents like PEG6000, Beeswax. The HMG based formulation was optimized by Central Composite design to study the effect of independent variable i.e. amount of Microcrystalline Cellulose and Crosspovidone on dependent variables like Disintegration time and % Drug release . from the results obtained, optimized formulation batch was selected which showed suitable disintegration time and % drug release.
IJCRT's Publication Details
Unique Identification Number - IJCRT25A6095
Paper ID - 290205
Page Number(s) - j399-j408
Pubished in - Volume 13 | Issue 6 | June 2025
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Vijay Suresh Surve, Dr. Sonia Singh, Dr. Rahul Aware, Ganesh Kute, "Solubility Enhancement of Spironolactone by Fluid Bed Hot Melt Granulation Technique", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.13, Issue 6, pp.j399-j408, June 2025, Available at :http://www.ijcrt.org/papers/IJCRT25A6095.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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