Published Paper Details:

Aim: To compare the efficacy of topical tacrolimus ointment with that of triamcinolone Acetonide ointment in patients with symptomatic oral lichen planus. Methods and Material: In this prospective randomized comparative study, 30 consecutive patients with oral lesions consistent clinically and histologically with OLP were recruited. The patients were divided into 2 groups to receive topical triamcinolone acetonide 0.1% or tacrolimus 0.1% ointment and treated for 6 weeks. The clinical effect of treatment in the patients were graded after 6 weeks by the treating physician using an ordinal score and recorded as worse, unchanged, improved or healed. Statistical analysis was done between no improvement and improvement-Healing group with Fisher's Exact Test. Results and conclusion: The results of this study allow the conclusion that treatment with topical tacrolimus 0.1% ointment four times daily induced a better initial therapeutic response than triamcinolone acetonide 0.1% ointment in patients with symptomatic OLP.