Published Paper Details:

Sustained release (sr) tablets are innovative oral dosage forms designed to deliver a drug at a predetermined rate for a prolonged period, maintaining constant therapeutic drug level in blood stream. The main objective of developing sustained release formulation is to enhanced patient compliance by reducing dosing frequency minimizing side effects and improving the efficacy of drug therapy. These tablets are formulated using various polymer such as hydroxypropyl methylcellulose (HMPC) ethyl cellulose and carbopol which control the drug release rate through diffusion or erosion mechanisms. The design approaches include matrix system, reservoir system and osmotic- controlled release systems. The release behavior of the drug depends on physiochemical properties like solubility, particle size and type of polymer used. Sustained release tablets are particularly useful for chronic conditions and pain management where long term therapy is essential. This drug delivery system not only maintain steady plasma drug concentration but also reduces fluctuation associated with conventional dosage forms. Therefore, sustained release technology represents a significant advancement in modern pharmaceutical formulation and drug delivery science.