Published Paper Details:

For creating mucoadhesive Carvedilol tablets, the current study used the mucilage of Ocimum basilicum seeds as a natural polymer in combination blends for long-lasting oral drug administration. Non-selective ?-blockers having ?1-blocking action, such as carvingilol, are frequently used to treat heart failure and hypertension. However, the drug's oral bioavailability is poor due to its short half-life, limited water solubility, and substantial first-pass metabolism. Therefore, it is preferable to use sustained release mucoadhesive formulations in order to increase therapeutic efficacy, decrease dosage frequency, and extend drug action. Ocimum basilicum L., a common medicinal herb. Its seeds contain a lot of mucilage, which can be used as a natural excipient in drug delivery systems because of its swelling, gel-forming, and mucoadhesive qualities. The study's objectives were to separate and describe the mucilage found in O. basilicum seeds and use this natural polymer to create sustained-release mucoadhesive Carvedilol tablets. Determining the drug concentration, assessing the physicochemical characteristics of formulations, and researching in vitro drug release profiles over a 12-hour period were the specific goals. An acetone-water (1:1) system was used to extract the mucilage from basil seeds, and FTIR and DSC methods were used to describe the results. Carvedilol sustained release tablets were made by direct compression with polymeric mixes containing varying amounts of basil mucilage. To ascertain flow characteristics, pre-compression parameters such as Hausner's ratio, Carr's Index, bulk density, tapped density, and angle of repose were measured. Hardness, friability, drug content, and weight variation were all examined after compression. Carvedilol's drug content was examined at 270 nm using UV-visible spectrophotometry. Drug release experiments were carried out in vitro in dissolving media for up to 12 hours. Flow property analysis showed all formulations had acceptable ranges for angle of repose, Carr's Index, and Hausner's ratio. After 12 hours, the percentage drug release was: 92.3%, 90.3%, 93.4%, 91.3%, 97.2%, 85.2%, 89.8%, 89.4%, and 87.9% for different polymer ratios. The formulation containing 5% basil mucilage with 5% synthetic polymer achieved the highest release (97.2%). The study demonstrated that Ocimum basilicum seed mucilage can be effectively utilized as a natural mucoadhesive polymer in the formulation of Carvedilol sustained release tablets. All formulations exhibited satisfactory physicochemical and mechanical properties with controlled drug release up to 12 hours. The 5% + 5% blend showed optimal release, indicating that basil seed mucilage is a promising, cost-effective, biocompatible excipient for sustained release drug delivery systems.