Published Paper Details:

Topical drug delivery has gained significant attention in recent years due to its ability to provide localized therapeutic effects while minimizing systemic side effects. Among various topical formulations, polymeric micelle-based gels have emerged as a promising platform for the delivery of anti-inflammatory drugs. Polymeric micelles are nanosized colloidal carriers formed by the self-assembly of amphiphilic block copolymers in aqueous solutions, offering enhanced solubility, stability, and controlled release of poorly water-soluble drugs. The incorporation of anti-inflammatory drugs into polymeric micelles improves their permeation through the stratum corneum, resulting in increased bioavailability at the site of inflammation. Additionally, polymeric micelle gels provide sustained drug release, reduce dosing frequency, and improve patient compliance. This literature review focuses on the formulation strategies, evaluation parameters, advantages, limitations, and potential applications of polymeric micelle-based topical gels for anti-inflammatory therapy. It also discusses critical factors influencing micelle formation, drug encapsulation efficiency, and release kinetics. Furthermore, the review highlights emerging opportunities, ongoing challenges, and future perspectives in the development of polymeric micelle-based topical drug delivery system. Understanding these aspects is essential for designing effective, safe, and patient-friendly topical formulations that can offer targeted therapy with minimal systematic exposure.