Published Paper Details:

Anti-wrinkle technology now in use is based on the fact that wrinkles are an inevitable consequence of aging owing to the destruction of scleroprotein fibers and considerable loss of collagen. Due to the stratum corneum's great resilience, conventional therapies like laser and Botulinum toxin have some disadvantages, such as adverse skin reactions, time-consuming treatment methods, and ineffective anti-wrinkle product penetration. In light of this, the cosmetics industry has developed a number of products based on solid and dissolvable microneedles (MNs) combined with antiwrinkle formulations, taking advantage of the patient-compliant technology of MNs to treat skin wrinkles. However, the high molecular weight of the medicines limits the use of these MNs for medication delivery. Although a greater variety of active agents can be delivered by hollow MNs (HMNs), this is an area of antiwrinkle technology that has not received much attention. In this study, we address this gap by discussing the potential of bioinspired 3D printed HMNs in the treatment of wrinkles on the skin. We contrast anti-wrinkling treatment alternatives from the past and present, as well as the methods and difficulties associated with their production and marketing.