Published Paper Details:

The aim of the study to evaluate the phytochemical properties, shelf life, and clinical effectiveness of Alocen gel (a formulation of Aloe vera and Centella asiatica) in reducing intravenous (IV)-induced thrombophlebitis among hospitalized patients. A one-group pretest-post-test design was adopted. The effectiveness of Alocen gel was assessed using the Modified Phlebitis Assessment Scale. Phytochemical analysis (albumin denaturation and heat-induced hemolysis assays) and microbial testing were conducted to establish anti-inflammatory activity and safety, while shelf-life stability was observed over 30 days. Statistical analysis included paired t-test and chi-square test. Phytochemical assays confirmed significant anti-inflammatory activity with a dose- dependent increase in inhibition, and microbial testing revealed the absence of harmful organisms. Shelf-life testing demonstrated stability without Odor or colour changes for 30 days. Clinically, pretest findings showed 75% mild, 15% moderate, and 10% severe thrombophlebitis, with no symptom-free cases. Post-test assessment revealed 85% symptom- free, 11.6% mild, and 3.3% moderate cases, with no severe thrombophlebitis. The mean pretest score (Mean = 1.56, SD = 1.130) reduced to the post-test score (Mean = 0.20, SD = 0.541), with a mean difference of 1.36. The paired t value of 13.412 (p < 0.0001) confirmed high effectiveness. Chi-square analysis indicated significant associations with selected demographic and clinical variables. No adverse reactions were reported. Alocen gel is a safe, stable, and effective herbal preparation for reducing IV- induced thrombophlebitis. Its phytochemical richness and clinical efficacy support its integration as a complementary nursing intervention. Further large-scale and long-term studies are recommended to validate its broader application.