Published Paper Details:

Drug repurposing, also known as drug repositioning, is an innovative and cost-effective strategy that involves identifying new therapeutic uses for existing drugs beyond their original medical indications. This approach has gained significant attention due to rising drug development costs, lengthy regulatory processes, and increasing global disease burden. Repurposed drugs benefit from established safety profiles, known pharmacokinetics, and reduced risk of failure compared to novel drug discovery. Among several repurposed agents, aspirin, metformin, and hydroxychloroquine have emerged as prominent examples with expanding therapeutic applications. Aspirin, traditionally used as an analgesic and antiplatelet agent, has demonstrated potential anticancer, anti-inflammatory, and neuroprotective effects. Metformin, primarily an antidiabetic drug, has shown promising roles in oncology, cardiovascular diseases, and metabolic disorders. Hydroxychloroquine, originally developed as an antimalarial agent, has been widely explored for autoimmune and inflammatory conditions. This review highlights the concept of drug repurposing, mechanisms involved, and recent advances in repurposing aspirin, metformin, and hydroxychloroquine for new clinical indications, along with challenges and future perspectives.