Published Paper Details:

Periodontitis is defined as an inflammatory disease, initiated by bacteria, that results in the destruction of the supporting tissues of the teeth. Among the periodontal diseases, periodontitis remains one of the leading cause which is characterised by chronic inflammation and progressive destruction of the supporting structures of the teeth. Traditional treatment therapy to eradicate the cause are supra-gingival scaling, sub-gingival curettage and root planning. These therapies focus on mechanical debridement and anti-infective strategies. Exosomes play a vital role in tissue regeneration. Exosomes are small extra cellular vesicles which are secreted by various cell types. Exosomes are of two types natural exosomes and engineered exosomes. Exosomes are secreted by almost all cells, including mesenchymal stem cells(MSCs), periodontal ligament stem cells(PDLSCs), dendritic cells(DCs), B cells, T cells and mast cells. Exosomes derived from mesenchymal stem cells show higher potential ability in the regeneration of alveolar bone, periodontal ligament and cementum. Mesenchymal stem cells have healing and immunomodulatory properties which allows them to be widely used in the field of medicine. The common source of MSCs are bone marrow(BM-MSCs), dental pulp(DPSCs), periodontal ligament(PDLSCs) and gingiva(GMSCs). The use of Exosome-based strategies in medicine and dentistry is associated due to their high potential.