Published Paper Details:

Three-dimensional (3D) printing is becoming an important technology in modern pharmaceutical manufacturing because it allows the creation of customized medicines whenever needed. A major innovation from this technology is the polypill, a single tablet that carries several drugs with different and adjustable release patterns. Such dosage forms are especially helpful for patients who take many medicines daily, such as those with long-term conditions like hypertension, diabetes, cardiovascular disorders, or age-related diseases. To successfully produce a 3D-printed polypill, detailed preformulation studies are essential. These investigations include examining the physical and chemical properties of the drugs, checking the compatibility of drug-excipient combinations, assessing thermal stability, and evaluating flow and rheological characteristics. These parameters ensure that the material can be printed properly and that the drugs remain stable throughout the process. This review outlines the key preformulation requirements and formulation approaches used in polypill development through various 3D-printing techniques such as fused deposition modeling (FDM), selective laser sintering (SLS), inkjet printing, and stereolithography (SLA). It also highlights the advantages and drawbacks of each method, regulatory considerations for 3D-printed medicines, and future research opportunities in this fast-growing field.