Published Paper Details:

Simple, sensitive, selective and Precise methods are developed for the UV-Visible Spectrophotometric methods have been developed for the estimation of five drugs VIZ., Lamotrigine (LTG), Loratadine (LOR), Losartan Potassium(LOS), Quetiapine fumarate (QTF) and Warfarin sodium (WAR). The method involves the addition of p- chloranilic acid to the drugs possessing a lone pair of electrons results in the formation of a charge transfer complex of the n-? type. The complex is formed by the lone pair of electrons donated by an n - donor to p- Chloranilic acid, a charge transfer reagent as an electron acceptor, through which a partial ionic bond (D+A-) is formed. p-CA solution in acetonitrile displays a maximum absorption peak at 450nm. The formation of colored solutions and the appearance of new peak are attributed to the formation of charge transfer ion pair complexes (D+A-).The broad peak with spike at 520nm is attributed to the radical anion of p-CA. In the present study area under curve (AUC) has been considered for the purpose of quantification of drugs as AUC is more accurate and precise than selecting one wavelength because AUC combines optical densities at the all the wave length. This method has been applied for the estimation of drugs in their pure form as well as in tablet formulation. The results of analysis have been validated statistically for linearity, accuracy, precision, LOD and LOQ.