Published Paper Details:

Recurrent aphthous stomatitis (RAS) and traumatic oral ulcers are painful lesions that significantly impair oral function and quality of life, arising from multifactorial causes including immune dysregulation, microbial imbalance, trauma, and nutritional or systemic factors. Herbal agents such as papaya (Carica papaya), Tulsi (Ocimum sanctum), Aloe vera, honey, and clove (Syzygium aromaticum) exhibit anti-inflammatory, antimicrobial, antioxidant, and wound-healing properties, supporting mucosal repair and reducing recurrence. Incorporation of these herbal agents into mucoadhesive systems, including gels, oral disintegrating strips, and lozenges, enables localized, sustained therapy with improved patient compliance, safety, and efficacy. Compared to conventional corticosteroid- or amlexanox-based treatments, herbal formulations offer a biocompatible, patient-friendly, and holistic approach. Future studies should focus on optimizing formulation strategies, standardizing phytochemical profiles, and conducting clinical validation to bridge traditional knowledge with modern pharmaceutical science, advancing effective and sustainable oral ulcer management.