Published Paper Details:

The present study aimed to formulate and evaluate oral fast dissolving thin films (ODFs) of Lansoprazole using both natural and synthetic polymers to improve patient compliance and achieve rapid therapeutic onset. Lansoprazole, a proton pump inhibitor used for treating acid-related gastrointestinal disorders, exhibits poor stability in acidic environments and undergoes extensive first-pass metabolism, which limits its bioavailability. To overcome these limitations, ODFs were prepared by the solvent casting method employing natural polymers such as Pullulan and Pectin, and synthetic polymers including Hydroxypropyl Methylcellulose (HPMC) and Polyvinyl Alcohol (PVA). The prepared films were evaluated for physicochemical parameters, mechanical strength, folding endurance, surface pH, disintegration time, and in vitro drug release. The optimized formulation exhibited desirable flexibility, uniform thickness, and rapid disintegration within seconds, releasing over 90% of the drug within 5 minutes. FTIR and DSC analyses confirmed the absence of drug-excipient interactions and stability of the formulation. The study concludes that fast dissolving Lansoprazole oral thin films can serve as a patient-friendly, stable, and effective dosage form for the rapid management of acid-related disorders, offering an alternative to conventional oral formulations.