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Calotropis gigantea Linn is a well-known medicinal plant often called milk weed. It has been used for a long time in the Unani, Ayurveda, and Siddha systems of medicine. This plant is native to India, China, and Malaysia, but it can be found almost everywhere around the world. Every part of the plant has been used for medicinal purposes and plays an important role in several Unani medicines used to treat various health issues. In traditional Unani writings, it is said to have many helpful properties, such as helping to get rid of worms, increasing appetite, reducing gas, tightening tissues, strengthening the body, helping to clear mucus, causing vomiting, making the body sweat, reducing inflammation, calming the mind, helping wounds to heal, acting as an antidote, and aiding digestion. It is used to treat conditions like asthma, stomach pain, cholera, menstrual issues, and toothache. The plant contains various chemicals like giganteol, alpha and beta calotropenol, beta-amyrin, and other substances. Calotropis gigantea has been found to have several health benefits, including helping with asthma, acting as an antioxidant, killing bacteria and viruses, helping wounds to heal, reducing inflammation, treating diarrhea, protecting the liver, and lowering blood sugar levels.The latex, leaves, flowers, bark, and roots of this plant are used as remedies for treating various health issues.