Published Paper Details:

Clarithromycin, a macrolide antibiotic used for respiratory and Helicobacter pylori infections, exhibits poor acid stability, short half-life, and variable bioavailability, leading to frequent dosing and poor patient compliance. This study aimed to develop extended-release mucoadhesive granules of clarithromycin using spray-drying technology to enhance gastric retention and sustain drug release. Formulations were prepared with mucoadhesive and controlled-release polymers including Carbopol 971P, HPMC, HPC, and polyethylene oxide. The granules were evaluated for micromeritic properties, drug content, swelling index, mucoadhesive strength, and in vitro release behavior. Polymer composition significantly affected release kinetics and adhesion characteristics. The optimized formulation exhibited sustained release following zero-order and Higuchi models, along with strong mucoadhesive properties ensuring prolonged gastric residence. Comparative evaluation with a marketed extended-release product confirmed therapeutic equivalence, indicating clinical relevance. The developed spray-dried mucoadhesive granules provide a promising, scalable approach to overcome limitations of conventional clarithromycin therapy, improving compliance and reducing dosing frequency