Published Paper Details:

Buccal drug delivery systems (BDDS)have emergedas apromisingalternativeto conventional oral drug delivery, offering advantages such as bypassing first-pass metabolism, rapid onset of action, and improved bioavailability for certain therapeutics. This review provides a comprehensive overview of the various approaches and technologies employed in buccal drug delivery,includingmucoadhesivesystems,patches,films,tablets,andgels.Thearticleexplores the anatomical and physiological characteristics of the buccal mucosa that influence drug absorption, alongside formulation strategies to enhance drug retention and permeation. Key polymers and excipients used in the development of buccal systems are discussed, with an emphasis on their role in mucoadhesion and drug release modulation.Additionally, the review outlines current in vitro and in vivo evaluation techniques used to assess the performance, efficacy, and safety of buccal formulations. Recent advances, challenges, and future prospects in the fieldare also highlighted, aiming to provide valuable insights for researchers and formulators developing novel buccal drug delivery platforms.