Published Paper Details:

In the present research work, the aim was to successfully formulate solid dispersion and incorporate it into a fast-dissolving tablet of promethazine theoclate, which were reduce or prevent nausea and vomiting. The main objective of research work was to increase the solubility of poorly water-soluble promethazine theoclate by preparing solid dispersions and subsequently formulating them into fast dissolving tablets (FDTs) to improve patient compliance and convenience. Solid dispersions were prepared by the fusion method and solvent evaporation method using appropriate excipients. Among various formulations, batch B6 was selected as the best formulation because it showed excellent performance with a percentage yield of 95%, drug content of 98%, and dissolution drug release of 94% at 30 minutes. The selected batch B6 was further formulated into fast dissolving tablets, which exhibited a disintegration time of 12 seconds, and a drug release of 99% within 30 minutes. These results confirm that solid dispersion technologywas an effective approach to enhance the solubility and dissolution rate of promethazine theoclate, thereby providing better therapeutic efficiency and patient compliance.