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ABSTRACT Job satisfaction is defined as "a pleasurable or positive emotional state resulting from the appraisal of one's job or job experiences" (Locke, 1976). Self-esteem refers to a person's overall sense of value or worth. It can be considered a measure of how much a person values, approves of, appreciates, prizes, or likes oneself (Rosenberg, 1965). Coping strategies refer to the specific behavioral and psychological efforts that people employ to master, tolerate, reduce, or minimize stressful events (Hamby, Grych, & Banyard, 2013). The present study examined self-esteem, coping strategies, and job satisfaction among nurses using quantitative techniques. A sample of 102 nurses, including 23 males and 79 females, within the age group of 22-39 years, was selected using random sampling from various hospitals in Kerala. The Rosenberg Self-Esteem Scale (Rosenberg, 1965), the Coping Scale (Hamby et al., 2013), and the Job Satisfaction Scale (Jayan & Dharmangadan, 2002) were administered. Data were analyzed using statistical methods such as correlation and t-test. The results revealed a significant relationship between self-esteem, coping strategies, and job satisfaction among nurses. Findings also indicated a significant difference in self-esteem with respect to gender, and a significant difference in coping strategies with respect to gender. However, no significant differences were found in job satisfaction with respect to gender, nor in self-esteem, coping strategies, or job satisfaction with respect to age.