Published Paper Details:

Diabetic wounds, particularly diabetic foot ulcers (DFUs), remain one of the most challenging complications of diabetes mellitus, affecting up to 25% of diabetic patients in their lifetime. Impaired wound healing arises from hyperglycemia-driven oxidative stress, chronic inflammation, angiogenic dysfunction, neuropathy, and a high susceptibility to infection. Conventional dressings often fail to address the multifactorial pathology of diabetic wounds. Hydrogel-based dressings have emerged as promising biomaterials, providing a moist wound environment, exudate absorption, and delivery of therapeutic agents. Carbopol, a synthetic cross-linked polyacrylic acid polymer, has demonstrated favourable physicochemical and rheological properties for hydrogel formulations. Meanwhile, Moringa oleifera, known as the "miracle tree," possesses root-derived phytochemicals such as flavonoids, alkaloids, tannins, and phenolic compounds, which exhibit potent antioxidant, anti-inflammatory, and antimicrobial effects. Incorporating Moringa oleifera root extract into Carbopol hydrogels offers a novel therapeutic strategy to accelerate wound closure, reduce infection, and modulate oxidative stress in diabetic wounds. This review explores the pathology of diabetic wounds, hydrogel-based interventions, formulation approaches, mechanisms of action, evaluation, applications, and future perspectives for Carbopol-based hydrogels containing Moringa oleifera root extract