Published Paper Details:

Objective: The present review aims to explore the therapeutic potential of Wrightia tinctoria (Roxb.) R. Br., emphasizing its traditional applications, phytochemical profile, pharmacological activities, mechanisms of action, safety aspects, and recent advancements in formulation strategies for improved clinical utility. Methodology: Relevant literature was collected from scientific databases including PubMed, Scopus, ScienceDirect, and Google Scholar, covering ethnopharmacological reports, phytochemical analyses, pharmacological investigations, and formulation studies up to 2024. Keywords used were "Wrightia tinctoria," "psoriasis," "flavonoids," "anti-inflammatory," "phytoconstituents," and "formulations." Articles focusing on traditional uses, bioactive compounds, pharmacological mechanisms, toxicity studies, and modern drug delivery systems were critically reviewed and analyzed. Results: Wrightia tinctoria was found to be traditionally employed in the treatment of dermatological, gastrointestinal, musculoskeletal, and infectious disorders. Phytochemical studies revealed the presence of flavonoids (quercetin, rutin, kaempferol), triterpenoids (lupeol, amyrin), sterols, alkaloids, glycosides, tannins, and fatty acids. Experimental evidence supports its anti-psoriatic, anti-inflammatory, antioxidant, antimicrobial, hepatoprotective, anticancer, and wound-healing activities. Mechanisms of action involve modulation of oxidative stress, inhibition of pro-inflammatory cytokines, normalization of keratinocyte proliferation, and regulation of immune pathways. Novel delivery systems such as nanoemulsions, liposomes, and phytosomes demonstrated improved bioavailability and therapeutic efficacy. Toxicological assessments indicated general safety at therapeutic doses, though comprehensive clinical validation is limited. Conclusion: Wrightia tinctoria integrates traditional knowledge with modern pharmacological evidence and represents a promising candidate for safe and effective herbal therapeutics, particularly in dermatological conditions such as psoriasis. However, large-scale clinical trials, standardization of extracts, and detailed mechanistic studies are necessary to establish its therapeutic reliability and facilitate regulatory acceptance.