Published Paper Details:

Cancer is a complex and multifaceted disease characterized by the uncontrolled growth and spread of abnormal cells. It can affect any part of the body and is a leading cause of death worldwide. Breast cancer is a disease in which malignant cells form in the tissues of the breast, often originating in the ducts or lobules. It is one of the most common types of cancer affecting the women worldwide. Lot of conventional therapies are available for the treatment of cancer, but the main problem associated with the treatment is the occurrence of serious adverse effects. Plants play a vital role in the discovery and development of anticancer agents due to their rich diversity of bioactive compounds with therapeutic potential. Many plant-derived secondary metabolites, such as alkaloids, flavonoids, and terpenoids, exhibit strong anticancer properties by targeting multiple cellular pathways involved in cancer development, including apoptosis induction, inhibition of angiogenesis, and suppression of metastasis. Network pharmacology is an emerging and highly relevant approach in modern drug discovery, especially for complex diseases like cancer. Unlike traditional "one drug, one target" strategies, network pharmacology embraces the complexity of biological systems by examining how drugs interact with multiple targets and pathways simultaneously. Viola tricolor, commonly known as wild pansy, heartsease, or Johnny jump-up, is a small annual or perennial herbaceous plant from the Violaceae family, native to Europe and parts of Asia. Phytochemical studies have identified a rich profile of bioactive compounds in Viola tricolor, including flavonoids (violanthin, rutin), phenolic acids (Caffeic and p-Coumaric acids), cyclotides, saponins, and carotenoids, which contribute to its wide spectrum of pharmacological activities. Recent in vitro studies have demonstrated that extracts of Viola tricolor exhibit cytotoxic effects against various cancer cell lines, including human cervical (HeLa), breast (MCF-7), and lung carcinoma cells, indicating potential anticancer activity. Due to its multi-component composition and traditional medicinal relevance, Viola tricolor is increasingly being studied through network pharmacology and molecular docking approaches to better understand its potential as a natural source of anticancer agents. The study utilized a network pharmacology approach to explore the anticancer potential of Viola tricolor, uncovering its multi-target and multi-pathway therapeutic actions. The analysis revealed that bioactive compounds in Viola tricolor interact with key cancer-related proteins such as TP53, PIK3CA, AKT1, JAK2, and ERBB2, which are central nodes in critical signaling pathways governing cell proliferation, apoptosis, and metastasis.