Published Paper Details:

ABSTRACT Background:Shukra Dhatu, the seventh tissue (dhatu) in Ayurvedic physiology, represents the most refined reproductive essence crucial for fertility and vitality. Objective biomarkers correlating classical ShukraDhatu assessment with modern reproductive health parameters remain underdeveloped. Objective: To systematically review the correlation between AshtaShukraDushti and modern semen analysis parameters, evaluate the development of composite scoring systems, validate hormonal and biochemical markers, and propose standardized diagnostic protocols for ShukraDhatu assessment. Methods: A comprehensive literature review was conducted following PRISMA guidelines, incorporating classical textual analysis with modern research findings. Databases searched included PubMed, Scopus, and Ayurvedic literature repositories from 2013-2025. Meta-analysis was performed where sufficient homogeneous studies existed, with narrative review for limited quantitative data. Results: Analysis of 248 patients across 14 studies revealed significant correlations between specific Shukra Dushti types and measurable semen parameters. Vataja Shukra Dushti correlated with oligozoospermia (r=0.72, p<0.001), while Kaphaja Dushti showed strong association with asthenozoospermia (r=0.68, p<0.01). Composite scoring systems integrating classical assessment with modern parameters demonstrated improved diagnostic accuracy (sensitivity 87%, specificity 82%) compared to conventional methods alone. Conclusions: Integration of classical Ayurvedic Shukra Dhatu assessment with modern biomarkers offers a comprehensive approach to reproductive health evaluation. Standardized diagnostic protocols incorporating both paradigms show promise for personalized fertility management.