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Abstract Background: Mental illness is often accompanied by stigma, misconceptions, and negative attitudes that hinder the reintegration of cured individuals into society. Families play a crucial role in the rehabilitation and acceptance of recovered persons. Objective: To assess the knowledge and attitude about mental illness and the acceptance of mentally ill cured persons among family members residing in selected areas of Indore, Madhya Pradesh. Methods: A descriptive cross-sectional study was conducted among 200 family members selected using a purposive sampling technique. A structured questionnaire assessed knowledge (20 items), attitude (15 statements), and acceptance (10 items). Data were analyzed using descriptive statistics (mean, SD, frequency, percentage) and inferential statistics (Chi-square test, p<0.05). Results: Out of 200 participants, 62% had adequate knowledge, 25% had moderate knowledge, while 13% demonstrated poor knowledge. A positive attitude was reported in 58% of participants, whereas 30% had a neutral and 12% had negative attitudes. Acceptance levels showed that 64% of family members were willing to reintegrate a cured person into their family life, but only 48% were comfortable with marriage alliances involving recovered patients. A significant association was found between knowledge levels and education (p<0.05), and between attitude and occupation (p<0.05). Conclusion: Although most family members showed adequate knowledge and favorable attitudes, gaps in acceptance--especially concerning marriage and social integration--were observed. Targeted awareness programs and community-based mental health education are recommended to reduce stigma and enhance acceptance of cured persons.