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ABSTRACT: The United Nations Convention unanimously define the reasonable accommodation of persons with disabilities as follows: ... "necessary and appropriate modification and adjustments not imposing a disproportionate or undue burden, where needed in a particular case, to ensure to persons with disabilities the enjoyment or exercise on an equal basis with others of all human rights and fundamental freedoms". The famous Genevan Philosopher-cum-Sociologist Jean-Jacques Rousseau capsulates; "Man is born free, and everywhere he is in chains" and an American Philosopher Henry David Thoreau observes as; "Man does not always live by laws and justice but by Grace", these three statements knock every sensitive mind to think seriously about the traditional evil practices of human discrimination on the basis of corporeally and psycho-socially deviations. But, the sufferings and subjugations of the marginalized persons across the globe are the never-ending miserable experiences. Scientific advancement in medical field and societal spaces enormously and tremendously hit the delicacies and intricacies of the status of marginalized person or groups of persons. Irrespective of the geographical frontiers, race, religion, culture, caste, creed, color, gender, polity, ethnicity and ethics the marginality in the society and in an advanced stage, the marginality among the marginals is still prevailing, proactive, alive and burning the very basic existence of the human diversity and mankind ecosystem. The persons with corporeally disabled are 'not only simply marginalized, but also the marginals among the marginalized too'. Millennium Development Sustainable Goals emphasizes on; Education for All, Health for All, Employability and Skill Oriented Opportunities for All - means irrespective of the psycho-physical barriers of an individual to enable them to attain self-reliance and humility. Innumerable number of policies and programs initiated, promoted and propagated by the governmental and non-governmental agencies at all stages of public-private-participatory modes of administration across the globe striving hard to minimize and dilute the gravity of the pain and agonal issues of the marginalized sect of persons with corporeally disabled to curb the extent and effects of evil practices of societal attitudes towards them. In this regard education i.e., elementary, secondary and higher education stages are pro introductory towards the eradicative measures related to inclusion of persons with disability in all spheres viz., socio-cultural-religious-political domains. Hence, the efforts are on with slow motion pace to publicize the process of transformation of social inclusion as a public friendly initiative through interdisciplinary, multidisciplinary and transdisciplinary approaches. In order to attain the meaningful outcomes through time oriented visionary tasks and schedules; well structured, rationally calculated, scientifically analyzed, holistically perceived and spirally managed specific discipline is essentially required to be existed independently. Accordingly, by the efforts of a few thinkers and educationists across the globe have resulted in establishment of Disability Studies as an independent discipline to address the issues of the persons with disability in a systematic, proper and rational manner duly encouraging the stake holders to come forward to raise their voices against the violence and discrimination they face. At this juncture, the very existence of the Disability Studies as an independent department or discipline of studies at higher education ladder, the quantum of humanly deserved and socio-culturally bound niceties will be more vested with the said discipline pushing the same towards the paradigm shift through expansion by means of interdisciplinary, multidisciplinary and transdisciplinary approaches. As a continuum of the assertions and arguments cited above, the well-structured and scientifically carved transdisciplinary mode of approach is expected to enhance the; exchange of knowledge and learning, focus on addressing a specific problem, embraced broader perspective, social interaction and collaboration, knowledge co-creation, equitable involvement, recognizing the interconnectedness, long-term perspective, implications and potential consequences of actions, innovative approaches, shared ownership of goals, processes and outcomes, all voices are heard and valued, flexibly organized structures etc.....so on and so forth. The aim of this paper is to emphasize the positive role of transdisciplinary approach followed by interdisciplinary and multidisciplinary to enhance and emphasize the quandaries and concerns of the victims, stakeholders, activists, visionaries and entrepreneurs of the filed of Disability Studies and compel the public administrative system to make this issue a 'mass concern' and constrain the society to modify and transform its biased attitude into an acceptable act for the persons with disability duly respecting their existence as they are in order to promote equity and equality of opportunity.