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Science and technology have completely transformed human life. Compared to earlier times, material comforts have increased manifold. However, alongside the rise in material comforts, human life values have also undergone change. Today, in this new environment, human beings are searching for new life values. Despite abundant material comforts, people are not finding true happiness and peace. Instead, they are experiencing stress and despair. Religions across the world have provided different kinds of life values. Yet, science has invalidated many traditional religious beliefs through its discoveries. As a result, modern intellectuals are once again searching for the meaning of life, happiness, and peace. The principles of Buddhism are based on reason, rationality, and wisdom. The Buddha neither accepted the eternity of the soul nor the existence of a creator God. He also rejected the notion of heavenly pleasures in the afterlife. Instead of faith-based religious doctrines, the Buddha accepted a scientific outlook and sought to make life happy and meaningful accordingly.